Well, now, this presents a chance to get on two educational soapboxes:
1. Never, ever, ever run two antivirus/security suite products on the same machine at the same time if both have realtime protection. These products use "virus like" techniques as part of the defenses they use, and each generally will see the other as a threat and engage in a battle to the death of your functioning system. In your case the two products you mention were not both of this class, but it is something that bears repeating for future readers.
2. Never, ever, ever use "system optimizer" packages and, most specifically, never ever, ever, ever use a registry cleaner. These things are virtually always a road to madness. They're snake oil, at best, and often cause far worse issues than they claim they will prevent.