Are you suggesting I uninstall BOTH Realtek drivers BEFORE doing anything else? Or just the one? I know it reinstalls itself, but I know I have one working and I've been having problems getting High Definition Audio to work since the latest update as well (I'm told that's better than Realtek and I've used it in the past, but now only Realtek seems to work).
For now I'm happy just uninstalling the McAfee things, then repairing Windows if needed. The problem started before I had double Realtek entries, so that's unrelated I believe. Your other suggestions are the things that I think could be related: McAfee, or broken files. It may take a few days to test it out as well, but I can record more content then just make a point of editing a lot of material to see if problems start occurring, and maybe even keep a Twitch page open too when I'm done.