Hi again ... just looked at your latest performance files.
Antivirus/Antimalware/Firewall
All the evidence points to overlapping programs here. Both the logs from the SysNative information app, and the logs you just created with Performance Monitor, show that full-time modules for ESET Smart Security, MalwareBytes AntiMalware, and Windows Defender are all loaded in and running. It might be that both an ESET firewall and the Windows Firewall are running as well. Of course, only one of each can run full time.
1) Make sure ESET's firewall is running
Check to see if your version of ESET has a firewall included (most of the versions I saw on their website do...), and then check in the ESET program interface (open ESET and have a look at it's main screen) -- and see if it shows its firewall as "On" or "Running".
2) Turn the Windows Firewall off
If the ESET firewall is running: turn the Windows Firewall off.
[Right-click Windows Start > select Control Panel > make sure the Large Icons view is selected > select Windows Firewall > select Turn Windows Firewall on or off > select Turn Windows Firewall off ... for BOTH Private and Public networks (there are two sections). NOTE: only do this if you are sure that ESET has a firewall that is running.
3) Uninstall Malwarebytes
It is running two full-time modules, whether you meant to have them on or not: mbam.exe and mbamservice.exe. These were taking up considerable system resources, as shown in your report. [The two highest users were ESET and MalwareBytes, Windows Defender got an "honorable mention" :) ] ....... I think it's best to just uninstall it for now: you can always try again with the free on-demand only version later ... (if you want to: it is a bit tricky to install ONLY the free on-demand version, because the trial offer business tends to keep popping up.... you usually have to opt-out of the free trial at least twice... )
4) Make sure that Windows Defender's real-time protection is turned off
Make sure that Windows Defender is turned off. If you have a full time antivirus and firewall, Windows Defender should not be running.
[Right-click Windows Start > select Control Panel > make sure the Large Icons view is selected > select Windows Defender > [at this point, if Windows Defender is turned off, you should see a message "this app has been turned off and is not monitoring your computer" ... if you don't see that message, Defender is likely ON] .... [To double-check if it's on, Click on Windows Start > Settings > System > Windows Defender (in the list on the left-hand side: if you don't see it, Defender is already turned off]
5) If Windows Defender's real-time protection is on, use a registry change to permanently disable it
Luckily, tenforums has a regfile you can download (once downloaded, you double-click the file and select merge)
The regfile is way way down, nearly at the end, of the following guide:
Windows Defender Real-time Protection - Turn On or Off in Windows 10 - Windows 10 Forums
Try these changes, and see if the system interrupts behave themselves better. Restart your computer after all the changes have been made.
Let's hope for the best!