Hi thanks,
I will try Microsoft defender to replace Avira.
I disabled Reaktek audio device from BIOS, disable Nvidia HD audio drivers (only install graphic driver) so I only use Scalett 2i4 audio drivers. In my case this is better than at the beginning, because it was like you, now I only have a "Bippppppp" sound bug latency sometimes, and somes crackling, but yes it's really annoying. I'am wasting my times in trying to resolve this issue while I would like to make some music...
Did u try to update BIOS, and drivers from Asus website ?