Also, Malwarebytes Premium runs in real time. This means all data coming into and out of your computer and running in your computer's memory are constantly being scanned. So you should not need to manually run a scan. But it never hurts to run manual scans - even if just for peace of mind.
BTW, Malwarebytes Premium plays well with Windows Defender - which is already included in Windows 8.x and Windows 10. While it is often heard we should never run two anti-malware solutions in real-time at the same time. This is because in the past, it was not uncommon for running two at once to cause conflicts. That is very rare these days, and again, Malwarebytes Premium and Windows Defender play well together without causing conflicts.
The other reason to not run two at once is simply because doing so may use lots of system resources (RAM and CPU cycles). While this is often true with some of the bigger security suites like Norton and McAfee, both Malwarebytes and Windows Defender are pretty light on resources.
FTR, I run both Windows Defender and Malwarebytes Premium on my 3 primary computers, including this one and have never experienced any conflicts or system performance issues. So I recommend you do too.
However, by default, Windows Defender (WD) is designed to step out of the way whenever a 3rd party anti-malware solution is installed. So, if you are running W8/W10, it is likely WD is not running. To enable WD, with Malwarebytes 3.x, simply open Malwarebytes control panel and on the Settings tab, scroll down to Windows Action Center. Change the setting to "Never register Malwarebytes in the Windows Action Center".
In Malwarebytes 4.x, click on the gear icon in the upper right corner, click the Security tab, then scroll down to Windows Security Center, move the slider for "Always register Malwarebytes in the Windows Security Center" to off (to the left).
This will enable Windows Defender's real-time component. Now Windows Defender will verify Malwarebytes has kept your system clean.
